Chromosome substitution strains

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August undefined, 2024

WebJan 23, 2024 · Chromosome substitution strains, also known as consomic strains, provide a simple model for exploring genetic influences. They consist of a panel of strains where one chromosome of a host strain is replaced by a homologous chromosome of a donor strain ( Matin et al., 1999; Singer et al., 2004; Ishii et al., 2011 ).

Chromosome substitution strains: gene discovery, …

WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. WebFeb 3, 2010 · Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-ChrA/J/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three … song icrimax

Analysing complex genetic traits with chromosome substitution strains ...

WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We … WebDec 16, 2008 · Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and … WebGenetic resistance to diet-induced obesity in chromosome substitution strains of mice.pdf. 2011-11-03 ... song - i could write a book - youtube - jazz

Chromosome substitution strains: gene discovery, …

Widespread epistasis regulates glucose homeostasis and gene

WebA chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substituted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for quantitative trait loci (QTLs) … WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... song i could sing of your love foreverWebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy 506 strains. In contrast, the third chromosome of the MHIII-D23 and 91R strains carries a loss-of-function ... song i could talk to you for hours

"WebJun 12, 2006 · An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting … " - Chromosome substitution strains

Chromosome substitution strains

WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to … WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, …

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WebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy506 strains. WebJun 29, 2016 · Selecting chromosome substitution strains (CSSs, also called consomic strains/lines) used in the search for quantitative trait loci (QTLs) consistently requires the identification of the respective phenotypic trait of interest and is simply based on a significant difference between a consomic and host strain. However, statistical significance as …

WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... WebChromosome substitution strains (CSSs) are a powerful complement to existing resources for studying multigenic traits. By partitioning the genome into a panel of …

WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain of the same species or a related species that will permit hybridization) by a suitable crossing programme. A Dictionary of Zoology MICHAEL ALLABY WebRecombinant inbred (RI) and chromosome substitution (CS) strain panels Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, …

WebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way ( 20 ). Each CSSs is an inbred strain that differs from the host strain by a single intact and homozygous chromosome on a defined and uniform genetic background.

WebChromosome substitution strains (CSS) were originally obtained as a gift from Dr. Joseph Nadeau (Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106). Each CSS is a homozygous inbred strain that is C57BL/6J with one chromosome pair from A/J. song id code for bonesWebJAX® Mice substrains were used to generate panels of consomic (chromosome substitution) strains for use as gene mapping tools 21. The Complex Trait Consortium (www.complextrait.org) plans to use JAX® Mice substrains as progenitor strains for the generation of >500 recombinant inbred strains 22. song i could die in your arms tonightWebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations,... song i could never be your womanWebChromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … smallest angle between two vectorsWebChromosome Substitution Strains: A New Way to Study Genetically Complex Traits Article Full-text available Feb 2006 Annie E Hill-Baskin Eric S Lander Joseph H Nadeau Many biological traits and... smallest and slimmest mobile in indiaWebMar 28, 2024 · 5.3 Chromosome Substitution or Consomic Strains 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains 5.5 Conplastic Strains 6. Outbreds and Closed Colonies 6.1 Outbreds 6.2 Closed Colonies 7. ES cell lines and iPS cell lines 8. References 1. Introduction Mice and rats used in the laboratory derive from a variety of sources. song i cry holyWebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in the host/parental strain on a defined and uniform genetic background. From:Handbook of Behavioral Neuroscience, 2016 Related terms: Phenotype Mutation Quantitative Trait Locus smallest animal ever existed on earth