Cisplatin and sodium thiosulfate

WebJul 6, 2024 · Now, results of the randomized, phase III SIOPEL 6 trial demonstrate that sodium thiosulfate (STS) has considerable efficacy in preventing cisplatin-induced … WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated.

Transtympanic Sodium Thiosulfate for Prevention of Cisplatin

WebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied the disappearance of cisplatin and carboplatin in aqueous solutions of thiosulfate at 37 degrees C by means of liquid chromatography. WebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium … flag of ms https://mrfridayfishfry.com

Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing …

WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... WebCisplatin-induced ototoxicity is caused by irreversible damage to hair cells in the cochlea hypothesized to be due to a combination of reactive oxygen species production and direct alkylation of DNA leading to cell death. Sodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status WebA randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer.  J Otolaryngol Head Neck Surg . 2024;48(1):4. doi: 10.1186/s40463-019-0327-x  PubMed Google Scholar Crossref flag of mount athos

HIGHLIGHTS OF PRESCRIBING INFORMATION PEDMARK ...

Category:High-dose cisplatin with sodium thiosulfate protection

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Cisplatin and sodium thiosulfate

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WebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below … WebJul 13, 2024 · Of the 101 participants, hearing loss occurred in 29 (63%) of the children who received cisplatin alone, compared with 18 (33%) of those who also got sodium …

Cisplatin and sodium thiosulfate

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WebJan 25, 2008 · Purpose: We determined if the potentially otoprotective agent sodium thiosulfate (STS) could be given 6 h after cisplatin without diminishing the … WebPEDMARK (sodium thiosulfate injection) is a sterile, preservative-free, clear, colorless solution in a single-dose vial for intravenous use with a pH between 7 and 9. Each vial contains the equivalent of 12.5 grams of sodium thiosulfate pentahydrate (provided as sodium thiosulfate anhydrous 8 grams) in 100 mL solution (125 mg/mL).

WebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in … WebMany cisplatin-protective agents have been evaluated: sodium thiosulfate , glutathione (GSH) , GSH ester , vitamin C , and sodium salicylate . However, to date, there are no methods that can completely prevent the loss of hair cells or the dysfunction of auditory nerves in cases of cisplatin-induced ototoxicity.

WebAug 11, 2024 · About Sodium Thiosulfate (STS) Cisplatin and other platinum compounds are essential chemotherapeutic components for many pediatric malignancies. Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer. WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss P.R. Brock and Others

WebSep 20, 2024 · On September 20, 2024, the Food and Drug Administration approved sodium thiosulfate (Pedmark, Fennec Pharmaceuticals Inc.) to reduce the risk of …

WebJun 21, 2024 · The 3-year rate of overall survival was 98% (95% CI, 88 to 100) among children in the cisplatin–sodium thiosulfate group and … canon camera metering modes explainedWebSep 22, 2024 · On September 20, 2024, the U.S. Food and Drug Administration (FDA) approved the use of sodium thiosulfate (Pedmark®) to reduce the risk of ototoxicity associated with cisplatin in pediatric patients aged 1 month and older with localized, nonmetastatic solid tumors. canon camera g7x mark 2WebThe chemotherapy agent cisplatin is essential for treatment of many paediatric and adolescent malignancies but in a large proportion of patients results in cisplatin-induced … canon camera memory chipWebToxicity of cisplatin can be decreased by concomitant administration of sodium thiosulfate, which perhaps chemically inactivates this platinum compound. We studied … flag of mullWebFeb 1, 2024 · Proper Use. Pedmark®: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will need to stay in place for at least 15 minutes. This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). canon camera new yorkWebApr 14, 2024 · Clinically, sodium thiosulfate (STS) is an approved drug for the treatment of acute cyanide and cisplatin toxicity. IR protective abilities of STS are reported with in-vivo models of myocardial IR as both preconditioning and post conditioning agent (Ravindran and Kurian 2024a ). canon camera news rumorsWebOct 6, 2024 · Sodium thiosulfate prevents hearing loss and is safe. Cisplatin belongs to a group of platinum-based chemotherapy drugs. Research has suggested that hearing … flag of montserrat