Cisplatin renal injury
WebApr 1, 2024 · However, cisplatin medication has many side effects, such as ototoxicity, neurotoxicity, nephrotoxicity, nausea, and vomiting [ 35, 97, 98, 99 ]. Nephrotoxicity occurs because cisplatin is taken up by the proximal tubular cells and can concentrate up to five times more than the cisplatin in the serum [ 35, 97 ]. WebNational Center for Biotechnology Information
Cisplatin renal injury
Did you know?
WebMar 29, 2024 · Cisplatin-Induced Acute Kidney Injury: Role of the Immune System . Inflammatory pathways have been linked to major pathophysiological mechanisms … WebFeb 5, 2010 · It is the urinary concentrations of furosemide that determine its diuretic effect. The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good ‘urinary response’ may be considered as a ‘proxy’ for having some residual renal function.
WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in …
WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has … WebAug 17, 2024 · Thirty percent of patients treated with cisplatin develop acute kidney injury, and all patients are at risk for long-term impacts on kidney function. There are currently no Federal Drug Administration-approved agents to prevent or …
WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …
WebApr 25, 2014 · Most of the cisplatin is trapped within the renal cortex [13, 22]. The concentration of cisplatin in the proximal tubular cells is 5 times higher than the serum … greenhorn restaurant blufftonWebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. … fly and drive mallorcaWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … greenhorn restaurant angels campWebMar 29, 2024 · Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations Cancers (Basel). … greenhorn resortWebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … greenhorn restaurant bluffton menuWebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often … fly and drive packages irelandWebSep 15, 2024 · Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. fly and drive mexico