WebDCLRE1A is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000).[supplied by OMIM] Function. The protein DCLRE1A … WebOrthologous to human DCLRE1A (DNA cross-link repair 1A). [provided by Alliance of Genome Resources, Apr 2024] Dclre1a DNA cross-link repair 1A [ (Norway rat)] Gene ID: 292127, updated on 9-Mar-2024. Summary. Predicted to enable 5'-3' exodeoxyribonuclease activity and damaged DNA binding activity. ... DNA cross-link repair 1A protein ...
DCLRE1A DNA cross-link repair 1A [ Homo sapiens …
WebSep 3, 2024 · Crosslinks (CLs) can be subdivided into DNA-intrastrand CLs, DNA-interstrand CLs (ICLs) and DNA-protein crosslinks (DPCs), and arise by various … WebOct 1, 2024 · Abstract. Proteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein … ms teams deleting chat history
Pharos : Target Details - DCLRE1A
Webfied that when mutated result in hypersensitivity to DNA crosslinking agents such as mitomycin C (MMC) or cisplatin (CDDP). For this reason, the proteins encoded by these genes are thought to function in the removal and repair of DNA interstrand crosslinks (ICLs) (1–3). Because of the complex nature of ICLs, several repair pathways are thought WebJul 29, 2010 · Mutations in 13 different genes implicated in repairing damaged DNA are known to be involved in the disease. Liu et al. (p. 693, published online 29 July) have identified a new factor, FAN1 (Fanconi anemia–associated nuclease 1), which they find to be associated with a complex of two of the FANC proteins, FANCI and FANCD2 (the ID … WebApr 9, 2024 · A spectacularly toxic form of damage, the interstrand crosslink (ICL), arises when two strands of duplex DNA become covalently linked [].The cellular response to ICLs is of great interest because several antitumour drugs, including platinum agents and mitomycin C, kill cancer cells by inducing ICLs [2, 3].More recently it has become … how to make lps beds