Small cholangiocyte
Webb27 nov. 2003 · To evaluate the differential gene expression between small and large cholangiocytes, microarray analysis was performed. Methods: Primary cultures of small … WebbCa(2+)-dependent protein kinase C (PKC) regulates small cholangiocyte function. Because gamma-aminobutyric acid (GABA) affects cell functions by activation of both Ca(2+) signaling and inhibition of AC, we sought to develop an in vivo model characterized by large cholangiocyte damage and proliferation of small ducts.
Small cholangiocyte
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Webb5 maj 2024 · ( a) SBEC cholangiocytes transfected with RhoU/Wrch1 or Hey2 plasmids and with an empty vector as a control. Cells were immunostained for RhoU/Wrch1 or Hey2 (red) 48 h after transfection. Nuclei... Webb5 okt. 2024 · To more conclusively address the relationship between β-catenin and NF-κB in BECs directly, we utilized immortalized mouse small cholangiocyte cells (SMCCs), which …
WebbSmall and large bile ducts and cholangiocytes expressed all AR receptor subtypes. Small (but not large) cholangiocytes respond to phenylephrine with increased proliferation via … Webb1 aug. 2008 · The stimulation of small cholangiocyte proliferation by HTMT dimaleate was blocked by the HRH1 antagonist terfenadine , the intracellular Ca 2+ chelator BAPTA/AM …
WebbThis cell line is aneuploid, will form colonies in soft agar and retains small cell carcinoma morphology and ultrastructure as well as APUD cell characteristics. The cells grow in aggregates, thus cell counts are not accurate. The cells stain positively for cytokeratins. The line can be adapted to grow in shaker flask or spinner flask systems. The N-myc … Webb27 nov. 2003 · Aims: We have shown that large and small cholangiocytes, which reside primarily in large and small intrahepatic bile ducts, respectively, have different functions and responses to injuries. However, there are no systematic studies of the molecular differences between small and large cholangiocytes, which would explain cholangiocyte …
WebbSmall and large cholangiocytes differ in nuclear-to-cytoplasmic ratio; small cholangiocytes have a higher ratio, suggesting they are less differentiated and have more capacity for plasticity as compared to large cholangiocytes ( Benedetti et al., 1996; Marzioni et al., 2002 ).
WebbTo address this question, we analyzed the migration-based characteristics of these cells that may help to understand their functions in vivo. Interestingly, dibutyryl cAMP induced marked filopodia formation and cdc42 activation in the normal mouse cholangiocyte (NMC)-small cell line compared with the NMC-large cell line. crystal fandeliers ceiling fansWebbSmall and large cholangiocytes differ in nuclear-to-cytoplasmic ratio; small cholangiocytes have a higher ratio, suggesting they are less differentiated and have more capacity for … crystal fang morgan lewisWebb1 feb. 2011 · Small cholangiocytes proliferate via activation of calcium (Ca2+)‐dependent signaling in response to pathological conditions that trigger the damage of large cyclic adenosine monophosphate–dependent cholangiocytes. Although our previous studies suggest that small cholangiocyte proliferation is regulated by the activation of … crystal family resort \u0026 spa belekWebb25 aug. 2024 · Small cell cholangiocytes (SMCCs) were plated at 2 × 10 5 cells/well in a six-well plate and transfected with 2.5 µg control or Wnt7b plasmid, described elsewhere, and 50 µM negative or β-catenin small interfering RNA (siRNA; Thermo Fisher Scientific, Waltham, MA) using Lipofectamine 3000 (Invitrogen, Carlsbad, CA), as per the … crystal fancher mdWebbWe found that both small and large cholangiocytes expressed GABA receptors. GABA: (i) induced apoptosis of large cholangiocytes and reduced large IBDM; (ii) decreased … crystal family resort \u0026 spa tripadvisorWebb12 juni 2024 · Interestingly, cholangiocyte-enriched transcription factors, Onecut1 and Onecut2, and cholangiocyte markers, Gpbar1 and Spp1, were significantly up-regulated in the HFM culture (figure 4(D)). Immunofluorescence analysis also confirmed that HFM-cultured CLCs maintained the expression of cholangiocyte markers (HNF1B, AQP1, … crystal family resort \\u0026 spa belekWebb18 okt. 2010 · Small and large bile ducts and cholangiocytes expressed all AR receptor subtypes. Small (but not large) cholangiocytes respond to phenylephrine with increased proliferation via the activation of IP 3 /Ca 2+ -dependent signaling. Phenylephrine stimulated the production of intracellular IP 3. crystal family resort \u0026 spa – all inclusive