WebJun 19, 2015 · Background Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as anti-cancer agent. Systemic administration of IL-12 often results in unacceptable toxicity; therefore, strategies to direct delivery of IL-12 to tumors are under investigation. The … WebMay 9, 2024 · In mouse models of subcutaneous adenocarcinoma and orthotopic melanoma, masked IL-12 delivered intravenously did not cause systemic IL-12 signalling …
Cancer immunotherapy using a membrane-bound interleukin-12 ... - PubMed
WebOct 1, 1997 · IL-12 is a novel heterodimeric cytokine that is produced predominantly by macrophages and other antigen presenting cells and serves as a key regulator of cell-mediated immunity. ... Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed … WebNov 12, 2024 · Deep IL-12 Primed T cells demonstrated superior efficacy compared to systemically administered IL-12, including increased survival, increased T cell expansion and activation in the tumor microenvironment, and low systemic exposure, with no observed systemic toxicity. malin wilson judo
Safety levels of systemic IL-12 induced by cDNA …
WebJun 15, 2024 · We conducted a phase II trial in patients with nonimmune-infiltrated melanoma using a combination of plasmid IL-12 electroporation (tavokinogene telseplasmid) and the PD-1 antibody pembrolizumab. WebDec 31, 2024 · Exosomal delivery has demonstrated limited systemic exposure to IL-12 in preclinical models and resulted in significant and prolonged PD activity and both local and systemic anti-tumor immune responses. The Phase 1 clinical trial is designed in two parts to evaluate safety, tolerability, PK and PD of exoIL-12 after single, ascending ... WebApr 27, 2024 · To safely harness the therapeutic potential of IL-12, it is critical to control IL-12 dosing and activity and to limit systemic effects from this potent immune stimulator. … malin wolf tranås