Web1 May 2024 · Furthermore, THBS1 acts as a major regulator of TGF-β activation via directly binding to the TGF-β1-LAP complex [43]. Furthermore, THBS1 promotes TGF-β1 secretion in MCs (cell line: Met-5A) [44], while TGF-β1 promotes THBS1 secretion in MCs, as shown in this study. These observations raise the possibility of the existence of a positive ... Web9 Apr 2024 · RT @Parsifaler: 8) The TGF-β cascade, which plays a major role in fibrosis, involves the binding of a ligand to a serine–threonine kinase type II receptor that recruits and phosphorylates a type I receptor. TGF-β is a potent stimulator of the synthesis of extracellular matrix proteins in most. 09 Apr 2024 04:30:46
Deciphering the complex role of thrombospondin-1 in
Web1 Jul 2024 · Because transforming growth factor-β (TGF-β) signaling is also increased in RDEB, and TSP1 is known to activate TGF-β, we investigated the role of TSP1 in TGF-β signaling in RDEB patient cells. Knockdown of TSP1 reduced phosphorylation of smad3 (a downstream target of TGF-β signaling) in RDEB primary fibroblasts, whereas … WebThis study was performed to explore the mechanism that THBS1 mediated pyroptosis by regulating the TGF-β signaling pathway in sepsis-induced AKI. Methods: The mouse … population qpv insee
TGF beta signaling pathway - Wikipedia
Web18 Oct 2024 · Abstract. TGF-β signaling pathway plays an important role in regulating cell proliferation and differentiation, embryonic development, bone formation, etc. LTBP1, … Web9 Dec 2024 · Thrombospondin-1 (THBS1) is a matrix glycoprotein that can affect fibrosis by activating TGF-β1, which plays a key role in wound repair and tissue regeneration; … Web1 Feb 2016 · THBS1 is also identified as a major physiological activator of TGF-b, a potent elicitor of EMT (41). A previous study showed that THBS1 is the chief tumor-specific ECM protein that froms the... sharon fortin